Interactive Visual Analysis of Networked Systems: Workflows for Two Industrial Domains

We report on a first study of interactive visual analysis of networked systems. Working with ABB Corporate Research and Ericsson Research, we have created workflows which demonstrate the potential of visualization in the domains of industrial automation and telecommunications. By a workflow in this context, we mean a sequence of visualizations and the actions for generating them. Visualizations can be any images that represent properties of the data sets analyzed, and actions typically either change the selection of data visualized or change the visualization by choice of technique or change of parameters

Parallel distributed algorithms of the beta-model of the small world graphs

The research goal is to develop a large-scale agent-based simulation environment to support implementations of Internet simulation applications.The Small Worlds (SW) graphs are used to model Web sites and social networks of Internet users. Each vertex represents the identity of a simple agent. In order to cope with scalability issues, we have to consider distributed parallel processing. The focus of this paper is to present two parallel-distributed algorithms for the construction of a particular type of SW graph called Beta-model. The first algorithm serializes the graph construction, while the second constructs the graph in parallel

A QUALITY SYSTEM FOR ENGINEERING EDUCATION

ABSTRACT This paper describes a quality system for programme evaluation (standard 12) focusing on its roles and artefacts. The system has been in use for three years and has during this time been proven useful for systematically developing the ten different engineering programmes at our institute. The quality system has components both to ensure an increase in education quality and a quality assurance of the engineering education. One interesting feature of the system is that it has components that adjust the quality system itself, allowing it to evolve over time. It is claimed that the quality system shifts the focus of the quality discussion from an isolated course-oriented one to one focused on aligning course aims with programme aims. The cost of the quality system, expressed in full-time positions, is also discussed

A scheme for compiling GHC to prolog using freeze

By using the metapredicate freeze, object-oriented programming and process simulation can, for several problems, be done directly in Prolog; although, this is a tiresome and untidy chore. Committed choice languages, on the other hand, provide an elegant syntax for these types of programs. A scheme is given for compiling Guarded Horn Clauses into sequential Prolog, using Prolog's own scheduling principle. Synchronization is implemented using freeze, thereby avoiding busy wait. This proves that Prolog, including freeze, gives enough strength to cover a wide range of object-oriented programming problems, without redefining unification or defining a non-depth-first execution system on top of Prolog. The report presents two versions of the idea: one for flat GHC and one for full GHC. For the flat GHC version, a compiler has been developed and found to give satsfactory behavior

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching

Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular connections are essential for the generation of cellular forms and shapes consistent with organ function. Tissue modulation is dependent on the fine-tuning of mechanical forces that are transmitted in part through the actin connection to E-cadherin as well as other components in the adherens junctions. In this report we show that p100 amotL2 forms a complex with E-cadherin that associates with radial actin filaments connecting cells over multiple layers. Genetic inactivation or depletion of amotL2 in epithelial cells in vitro or zebrafish and mouse in vivo, resulted in the loss of contractile actin filaments and perturbed epithelial packing geometry. We further showed that AMOTL2 mRNA and protein was expressed in the trophectoderm of human and mouse blastocysts. Genetic inactivation of amotL2 did not affect cellular differentiation but blocked hatching of the blastocysts from the zona pellucida. These results were mimicked by treatment with the myosin II inhibitor blebbistatin. We propose that the tension generated by the E-cadherin/AmotL2/actin filaments plays a crucial role in developmental processes such as epithelial geometrical packing as well as generation of forces required for blastocyst hatching.Peer reviewe

An electrostatic potassium channel opener targeting the final voltage sensor transition

Free polyunsaturated fatty acids (PUFAs) modulate the voltage dependence of voltage-gated ion channels. As an important consequence thereof, PUFAs can suppress epileptic seizures and cardiac arrhythmia. However, molecular details for the interaction between PUFA and ion channels are not well understood. In this study, we have localized the site of action for PUFAs on the voltage-gated Shaker K channel by introducing positive charges on the channel surface, which potentiated the PUFA effect. Furthermore, we found that PUFA mainly affects the final voltage sensor movement, which is closely linked to channel opening, and that specific charges at the extracellular end of the voltage sensor are critical for the PUFA effect. Because different voltage-gated K channels have different charge profiles, this implies channel-specific PUFA effects. The identified site and the pharmacological mechanism will potentially be very useful in future drug design of small-molecule compounds specifically targeting neuronal and cardiac excitability

Cell fusions in mammals

Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defense system. Additionally, cell fusions participate in tissue repair and may be important to cancer development and progression. A large number of factors appear to regulate cell fusions, including receptors and ligands, membrane domain organizing proteins, proteases, signaling molecules and fusogenic proteins forming alpha-helical bundles that bring membranes close together. The syncytin family of proteins represent true fusogens and the founding member, syncytin-1, has been documented to be involved in fusions between placental trophoblasts, between cancer cells and between cancer cells and host cells. We review the literature with emphasis on the syncytin family and propose that syncytins may represent universal fusogens in primates and rodents, which work together with a number of other proteins to regulate the cell fusion machinery

Competition and substitution between public transport modes

The management and understanding of modal split between public transport (PT) modes is of interest for numerous reasons. It may, for example, be desirable to stimulate passengers to switch from crowded buses and over to higher capacity rail. This requires a good understanding of drivers of transit modal substitution. The evidence put forward in this paper is based on more than 150 empirically estimated cross elasticities between PT modes from over 20 sources collected from Australia, Europe and USA. These sources include scientifically published evidence as well as grey literature. This evidence is coded into a database from which our paper presents and analyses the available cross-PT-modal demand relations. We focus on evidence for how fares, travel time and service intervals on PT ‘mode A’ affect the demand for PT ‘mode B’. Despite generally low levels of substitution between PT modes, passengers are particularly sensitive to in-vehicle, access/egress and waiting time in choosing PT mode and less so for fare variations. In general, rail demand is less sensitive to changes in bus than bus demand is to changes in rail. We also find that peak-hour demand more markedly switches between PT modes than off-peak demand does